Adverse Events Diagnosed within Three Days of Vaccine Administration in Dogs

“Retroactive twoyear analysis with 1,427,534 dogs showing the rabies vaccine is the most problematic, small breed dogs have a higher risk, especially when given multiple vaccinations.“Premarketing safety studies, when fiscally or logistically limited in size, will remain limited in power to detect rare adverse events that may be more common among animals with particular risk factors.”

Duration of Immunity for Canine and Feline Vaccines: A Review

“Vaccination should not be considered an innocuous procedure, since vaccines may have harmful consequences to patients as well as owners, thus use those vaccines that are required, give them only as often as is necessary and vaccinate as many cats and dogs in the population as possible.”

Canine Nomograph Evaluation Improves Puppy Immunization

“Regardless of whether nomograph was done for a dam, authors support WASAVA guidelines in urging that all puppies are tested for antibody titers by 6 months to detect failure of immunization during this highest risk period. The presumption that vaccination is equivalent to immunization may lead to unfortunate, but avoidable surprises.”

Vaccine-Induced Autoimmunity in the Dog

Demonstrated “the vaccination of dogs using a routine protocol and commonly used vaccines induces autoantibodies.”

Rabies in Vaccinated Dog and Cats in the United States, 1997-2001

“Veterinarians should include rabies in the differential diagnosis for any dog or cat with clinical signs compatible with rabies regardless of vaccination history. Continued surveillance is imperative to document vaccination failure and identify trends related to vaccination failure.”

Canine Parvovirus Vaccination and Immunisation Failures: Are We Far from Disease Eradication?

“Antibody testing to determine the optimal time for vaccinations of pups and adults and homogenous coverage of dog population are the next logical steps towards achieving disease eradication or at least an improvement of the current situation.”

What’s missing? Post marketing surveillance and reports of adverse reactions!

In veterinary medicine, there is no requirement to report adverse events (known or suspected) following vaccination. Although strongly encouraged, formal reports from veterinarians to the U.S. Department of Agriculture (USDA) or the vaccine manufacturer are seldom filed.

AAHA Vaccine Adverse Reactions